Description
Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V.
Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin.
It recognizes the sequence R-G-D in its ligands.
Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1.
Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes.
This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1